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Interestingly, the LIN28B/MYC/miR-34a-5p pathway can be therapeutically exploited: in fact, when using LIN28B inhibitors, miR-34a-5p increases and PKM2 decreases while tumor growth and lung metastasis are suppressed [42]

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The practical questions are: what receptor pathway does it use, what human data exists, what is the current approval status, and how does it compare with approved GLP-1 options